pTDP43 | IHC

Test DetailsDetection of the antigen in postmortem formalin-fixed and paraffin embedded brain tissue
ComponentsClone pS409/410 performed as an LDT on Ventana Ultra platform
PerformedMonday – Friday
Turnaround2 – 3 business days
Specimen requirementsFFPE postmortem brain tissue

Minimum specimen requirement: 2 slides.
If requesting interpretation, please submit an H&E slide.
Sample collectionTesting currently limited to WU autopsy cases
Unacceptable ConditionsMelted block; brain tissue pre-treated with formic acid
CPT Code(s)NA
MiscellaneousThis immunohistochemical test was developed by AMP Core Labs in collaboration with the Division of Neuropathology, WU Department of Pathology and Immunology. The tests were validated for use on formalin-fixed postmortem brain tissues; potential effects of formic acid treatment have not been evaluated. The tests are performed using a polymer-based detection system and instrumentation by Ventana Medical Systems. Additional details regarding the procedures are available on request. Results must be interpreted in conjunction with available clinical and pathologic information.