IHC

Squamous cell and subsets of adenocarcinoma and transitional cell carcinoma, prostate basal cells, hyperplastic prostate versus prostate cancer

Lymphatic endothelium, lymphangiomas, Kaposi sarcomas and subset of angiosarcomas.

Skeletal and smooth muscle tumors

 Distinguishes between lobular and ductal epithelial proliferations

Identification of epithelial membrane antigen in adenocarcinomas of secretory epithelium, malignant mesothelioma, renal cell carcinoma and meningiomas

Expressed in breast carcinoma and urothelial carcinoma

Erythroid cell precursors, red blood cells and erythroid leukemias

Used for the semi-quantitative detection of HER2 antigen in neoplastic breast tissue.

Used as a melanocyte marker to aid in the differential diagnosis of melanocytic verses non-melanocytic tumors.

Used as a melanocyte marker to aid in the differential diagnosis of melanocytic verses non-melanocytic tumors.

To distinguish malignant rhabdoid tumors and other malignant central nervous system tumors

Cell proliferation marker

Granulocytes and histiocytes. Marker for leukemias and histiocytic neoplasms

Breast carcinoma, salivary gland lesion and sweat gland carcinoma

Melanocytic lesions

Identify DNA mismatch repair protein

Mouse monoclonal antibody directed against mismatch repair protein MSH2. This antibody is used in the identification of microsatellite instability.

Identify DNA mismatch repair protein

B cells in germinal centers, plasma cells, activated T cells and related hematolymphoid neoplasmas. Along with CD30 used as a marker for Hodgkin's and reed Sternberg cells

Rhabdomyosarcoma

Mouse monoclonal antibody directed against napsin which is a pepsin like aspartic proteinase. High expression is seen is lung and kidney

Neural, neuroendocrine and endocrine tumors

Seminoma, dysgerminoma, embryonal carcinoma

Detection of the antigen in postmortem, formalin-fixed and paraffin embedded brain tissue

Detection of the antigen in postmortem, formalin-fixed and paraffin embedded brain tissue

HPV associated dysplasia / carcinoma

Used to aid in the identification of basal cells in the prostate and squamous cell carcinoma in the lung.

Tumor suppresor

Differntiates benign from malignant prostatic lesions. Breast myoepithelial cells; squamous cell carcinoma

Normal and neoplastic B cells, Reed Sternberg cells

Paired Box (PAX) family of transcription factors

DNA mismatch repair protein

Prognostic and predictive marker in breast and other carcinomas

Detection of antigen in postmortem, formalin fixed and paraffin embedded brain tissue

Detection of the antigen in postmortem formalin-fixed and paraffin embedded brain tissue

Renal cell carcinoma

Neural tumors (glial and Schwann cells), melanoma, chondrocytes

The detection of Smooth Muscle Myosin heavy chain. It is helpful in distinguishing between benign sclerosing breast lesions and infiltrating carcinomas.

Neural and neuroendocrine tumors

cortical thymocytes, megakaryocytes, normal mature B and T lymphocytes, B-ALL and T-ALL

Used to aid in the identification of triple negative metastatic carcinoma of breast origin.