IHC

Alpha smooth muscle isoforms, myoepithelium etc.

It is expressed in only few cells in the developing and mature nervous system Ð glial cells, neurons, endothelial cells and pericytes.

Detection of androgen receptors.  Primarily used in carcinomas of the breast and prostate.

Follicular lymphoma, other B and T cell lymphomas, soft tissue tumors

Follicular lymphoma, follicular center B cells, DLBCL subset

Detection of the antigen in postmortem, formalin fixed and paraffin embedded tissue

Fibromatosis, colorectal carcinoma

Detection of BK (SV40 family) virus in post-transplant kidney

Gastrointestinal stromal tumors, mast cells

Used to aid in the characterization of lymphoma.

Pancreas, GI, ovary, lung and transitional cell carcinoma

Non-mucinous ovarian carcinoma, serous and endometroid adenocarcinomas

Thyroid medullary carcinoma, thyroid C cells

Normal and reactive mesothelium, mesothelioma and distinguishing mesothelioma from adeocarcinoma

Pan - T cell - thymic and peripheral T lymphocytes, mast cells, NK cells, T cell lymphoma subsets

Normal follicular dendritic cells; dendritic cell tumor/sarcomas, B cell subset

B-CLL, Small lymphocytic (B cell) lymphoma

Normal and neoplastic T cells

Mononuclear Hodgkin's cells, Reed Sternberg cells of Hodgkin's lymphoma and anaplastic large cell lymphoma; plasma cells

Endothelium, vascular neoplasms, plasma cells

Myeloid progenitor cells, endothelium, vascular tumors

Neural and neuroendocrine tumor, soft tissue tumor subset, NK cells, plasma and T-cell subsets

Neural and neuroendocrine tumor, follicular center cell lymphoma

Megakaryocytes, platelets

Macrophages

Macrophages

Thymocytes and mature T cells

Pan B cells

Cytotoxic / suppressor T cells

T cells, cortical thymocytes, Ewing's sarcoma / PNET, sex cord stromal tumors

Enteric differentitation, GI tumors, colorectal carcinoma, GI origin of metastatic adenocarcinomas and carcinoids. Mucinous carcinomas of the ovary

Neuroendocrine neoplasms

Mantle cell lymphoma, breast cancer

Normal and abnormal epithelial cells and to determine lineage of poorly differentiated tumors

Variety of epithelium and epithelial malignancies including adenocarcinoma of colon, stomach, pancreas, biliary tract and breast

GI tumors, transitional cell carcinoma, Merkel cell tumors

Tumors with squamous differentiation, malignant mesothelioma versus adenocarcinoma of lung, myopeithelial cells, benign vs. malignant breast intraductal proliferation

Normal and neoplastic cells of ovary, lung and breast. Often used in conjunction with CK20

Found in most simple epithelium. Adenocarcinomas and most non-keratinizing squamous carcinomas. Will stain Paget cells.