beta-Amyloid (1-42) | IHC
| Test Details | Detection of the antigen in postmortem, formalin fixed and paraffin embedded tissue |
| Components | Clone H31L21 performed as an LDT on Ventana Ultra platform |
| Methodology | Immunohistochemistry |
| Performed | Monday – Friday |
| Turnaround | 2 – 3 business days |
| Specimen requirements | FFPE postmortem brain tissue Minimum slide requirement: 2 slides. If requesting interpretation, please submit an H&E slide. |
| Sample collection | Testing currently limited to WU autopsy cases |
| Unacceptable Conditions | Melted block; brain tissue pre-treated with formic acid |
| CPT Code(s) | NA |
| Miscellaneous | This immunohistochemical test was developed by AMP Core Labs in collaboration with the Division of Neuropathology, WU Department of Pathology and Immunology. The tests were validated for use on formalin-fixed postmortem brain tissues; potential effects of formic acid treatment have not been evaluated. The tests are performed using a polymer-based detection system and instrumentation by Ventana Medical Systems. Additional details regarding the procedures are available on request. Results must be interpreted in conjunction with available clinical and pathologic information. |